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Chemistry at the Core

We design innovative small molecules that precisely inhibit clinically proven kinase targets to solve for the dual challenges of resistance and selectivity.

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Built for Patients

We partner with physician-scientists to identify patient needs and the limitations of existing therapies.

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Driven by Purpose

We are passionate about using our expertise to address the needs of patients with cancer.

Meet our Team
Sophie Higgins

Sophie Higgins, MPH

Regulatory Affairs

Rebecca Hoffman

Human Resources

Lisa Holland, MBA, MSN

Market Access
Joshua Horan

Joshua Horan, PhD

Vice President, Chemistry
Brett Hubbard, RN

Brett Hubbard, RN

Pharmacovigilance

Our clinical trials

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A Phase 1/2 study of zidesamtinib (NVL-520) in patients with advanced ROS1-positive NSCLC and other solid tumors.

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A Phase 1/2 study of neladalkib (NVL-655) in patients with advanced ALK-positive NSCLC and other solid tumors.

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A Phase 3 study of neladalkib (NVL-655) in patients with TKI-naïve ALK-positive NSCLC.

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A Phase 1 study of NVL-330 in patients with advanced HER2-altered NSCLC.

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Apr 01, 2025

Nuvalent to Participate in the Stifel 2025 Virtual Targeted Oncology Forum

Mar 25, 2025

Nuvalent to Present New Preclinical Data on ALK-Selective Inhibitor, Neladalkib, and ROS1-Selective Inhibitor, Zidesamtinib, at AACR Annual Meeting 2025

Feb 28, 2025

Nuvalent to Participate in Upcoming March Investor Conferences

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